HCID 87950499, Verbindung → HCID 18469986, Verbindung

HRID 2228448Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2228448
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:36])[CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:35])[C:31]([F:34])([F:33])[F:32])=[CH:25][CH:24]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[F:33][C:31]([F:32])([F:34])[C:30]([NH:29][C:26]1[CH:25]=[CH:24][C:23]([CH2:22][CH2:21][C:20](=[O:36])[C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[CH:15][CH:16]=2)=[CH:28][CH:27]=1)=[O:35]

Komponenten

4

Edukt 1

HCID 87950499HCID 87950499, Verbindung

Produkt 1

HCID 18469986HCID 18469986, VerbindungAusbeute 96,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A suspension of 4-(4-{3-[4-(2,2,2-trifluoroacetylamino)phenyl]propionyl}-phenyl)piperazine-1-carboxylic acid tert-butyl ester (2.5 g, 4.95 mmol) in dichloromethane (10 mL) and trifluoroacetic acid (10 mL) was stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo and diluted with water. The resultant white solid was collected, washed with water, dried in vacuo to give the title compound (1.93 g, 96%). The product was used in the next step without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. additiondiluted with water
  3. customThe resultant white solid was collected
  4. washwashed with water
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9c4ad7f779a94c68a26c37476c9eec9a
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06417186B1

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