Piperazine → 1-Phenyl-4-(1-piperazinyl)-1H-pyrazolo[3,4-d]pyrimidine

HRID 2230099

Reaktionsgleichung

Reaktionsgleichung von HRID 2230099
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[N:13]=[CH:12][N:11]=[C:10]2[N:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:15]=[CH:16][C:9]=12>C(O)(C)C>[C:17]1([N:14]2[C:10]3=[N:11][CH:12]=[N:13][C:8]([N:1]4[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]4)=[C:9]3[CH:16]=[N:15]2)[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Komponenten

4

Edukt 2

HCID 4837PiperazineHCID 2197524-Chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

Produkt 1

HCID 8556141-Phenyl-4-(1-piperazinyl)-1H-pyrazolo[3,4-d]pyrimidineAusbeute 88 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To an isopropanol solution (10 mL) of piperazine (3.74 g, 43.4 mmol), 4-chloro-1-phenylpyrazolo[3,4-d]pyrimidine (100 g, 4.34 mmol) described in J. Org. Chem., 21: 1240-1256 (1956) was added, followed by heating under reflux for 6 hours. The reaction solution was concentrated, saturated brine was added thereto, the mixture was extracted with chloroform, the extract was washed with saturated brine and dried over anhydrous sodium sulfate, and then the solvent was evaporated to give the target compound (1.07 g, 3.82 mmol).

Aufarbeitung

  1. addition, 21: 1240-1256 (1956) was added
  2. temperatureby heating
  3. temperatureunder reflux for 6 hours
  4. concentrationThe reaction solution was concentrated
  5. additionsaturated brine was added
  6. extractionthe mixture was extracted with chloroform
  7. washthe extract was washed with saturated brine
  8. dry with materialdried over anhydrous sodium sulfate
  9. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-8a92fe3fcece4356bb472dc60d350135
Quelldatensatz
uspto-grants-2002_07
Patentnummer
US06423716B1

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