Hydrochloric Acid → 4-(3-Amino-5-methoxycarbonylphenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine.dihydrochloride
Reaktionsgleichung
C([NH:4][C:5]1[CH:6]=[C:7]([N:15]2[C:20](=[O:21])[C:19]([CH2:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[N:18][C:17]3[CH:29]=[CH:30][CH:31]=[N:32][C:16]2=3)[CH:8]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1)(=O)C.[ClH:33]>CO>[ClH:33].[ClH:33].[NH2:4][C:5]1[CH:6]=[C:7]([N:15]2[C:20](=[O:21])[C:19]([CH2:22][C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[N:18][C:17]3[CH:29]=[CH:30][CH:31]=[N:32][C:16]2=3)[CH:8]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[CH:10]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 4-(3-acetylamino-5-methoxycarbonylphenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine (847 mg) and hydrochloric acid (35%, 1 ml) in methanol (10 ml) was stirred under reflux for 2 hours. After cooling, the resultant precipitate was collected and washed with methanol to give 4-(3-amino-5-methoxycarbonylphenyl)-2-(3-pyridylmethyl)-3-oxo-3,4-dihydropyrido[2,3-b]pyrazinedihydrochloride (612 mg).