Methyl iodide → HCID 13823248, Verbindung

HRID 2231191Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2231191
[Cl:1][C:2]1[CH:3]=[C:4]([N:20]2[C:25](=[O:26])[NH:24][C:23](=[O:27])[CH2:22][NH:21]2)[CH:5]=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][CH:10]=1.[H-].[Na+].[CH3:30]I>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:20]2[C:25](=[O:26])[N:24]([CH3:30])[C:23](=[O:27])[CH2:22][NH:21]2)[CH:5]=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[CH:10]=[CH:11][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 13823230HCID 13823230, Verbindung

Produkt 1

HCID 13823248HCID 13823248, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1 g of 2-[3,5-dichloro-4-(4-methylsulfonylphenoxy)phenyl]hexahydro-1,2,4-triazine-3,5-dione was dissolved in 10 ml of dimethylformamide and, with exclusion of moisture, about 250 mg of a suspension of sodium hydride were added. After the evolution of gases was complete, 1 ml of methyl iodide was added, with stirring, and then the mixture was stirred at room temperature for a further 5 h. The reaction solution was poured onto water, and the precipitate was filtered off with suction and recrystallized from isopropanol, melting point 217° C.

Aufarbeitung

  1. additionwere added
  2. stirringthe mixture was stirred at room temperature for a further 5 h
  3. additionThe reaction solution was poured onto water
  4. filtrationthe precipitate was filtered off with suction
  5. customrecrystallized from isopropanol, melting point 217° C.

Quellen und Nachweise

ORD-Eintrag
ord-85ece2ff6edc4d279c52f9fdd29ced73
Quelldatensatz
uspto-grants-1988_11
Patentnummer
US04782056

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