N-cyclopropylbenzene-1,2-diamine → 1-Cyclopropyl-2-methyl-1H-benzimidazole

HRID 2231243Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2231243
[CH:1]1([NH:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[NH2:11])[CH2:3][CH2:2]1.[CH2:12](C(CC)(CC)C([O-])([O-])[O-])[CH3:13]>C(OCC)(=O)C>[CH:1]1([N:4]2[C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=3[N:11]=[C:12]2[CH3:13])[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 10582926N-cyclopropylbenzene-1,2-diamineHCID 21875354Triethylorthoaceate

Produkt 1

HCID 212862831-Cyclopropyl-2-methyl-1H-benzimidazoleAusbeute 94,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 1.71 g (0.0115 mole) of N-cyclopropyl-1,2-phenylenediamine and 2.12 ml (0.0115 mole) of triethylorthoacetate in 50 ml of ethyl acetate was heated to reflux for 2 hours. The solvent was removed and the residue partitioned between chloroform and water. The organic phase was separated, dried over sodium sulfate and concentrated to give 1.87 g of a brown oil.

Aufarbeitung

  1. temperatureto reflux for 2 hours
  2. customThe solvent was removed
  3. customthe residue partitioned between chloroform and water
  4. customThe organic phase was separated
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-675887b0d42e428d85ed6c177ce0e9ed
Quelldatensatz
uspto-grants-1988_11
Patentnummer
US04782050

Notizen zur Reaktion

Wird geladen…