Acetyl chloride → 1-Acetyl-4-phenylimidazole

HRID 2231253Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2231253
[C:1]1([C:7]2[N:8]=[CH:9][NH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[C:14](Cl)(=[O:16])[CH3:15]>O1CCCC1>[C:14]([N:10]1[CH:11]=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]=[CH:9]1)(=[O:16])[CH3:15]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 24758Sodium hydrideHCID 178418822HCID 178418822, Verbindung

Produkt 1

HCID 108214021-Acetyl-4-phenylimidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4-phenylimidazole in 40 ml of tetrahydrofuran was added portionwise 1.66 g of 50% sodium hydride. After stirring for 20 minutes, 2.46 ml of acetyl chloride was added over 10 minutes and the reaction mixture allowed to stir overnight at room temperature. The reaction was filtered and the filtrate concentrated to give 4 g of crude product which was purified by chromatographing on 150 g of silica gel using 5% methanol in chloroform as eluent, 2.88 g.

Aufarbeitung

  1. stirringto stir overnight at room temperature
  2. filtrationThe reaction was filtered
  3. concentrationthe filtrate concentrated

Quellen und Nachweise

ORD-Eintrag
ord-912abe7593c647b99ca32f4469d7bc09
Quelldatensatz
uspto-grants-1988_11
Patentnummer
US04782050

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