N~1~-Ethyl-4-fluorobenzene-1,2-diamine → 1-ethyl-5-fluoro-2-methylbenzimidazole

HRID 2231263Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2231263
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[NH2:11])[CH3:2].[CH2:12](C(CC)(CC)C([O-])([O-])[O-])[CH3:13]>C(O)C>[CH2:1]([N:3]1[C:4]2[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=2[N:11]=[C:12]1[CH3:13])[CH3:2]

Komponenten

4

Edukt 2

HCID 21286303N~1~-Ethyl-4-fluorobenzene-1,2-diamineHCID 21875354Triethylorthoaceate

Produkt 1

HCID 27743771-ethyl-5-fluoro-2-methylbenzimidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 2.92 g of N-ethyl-4-fluorophenylenediamine in 15 ml of ethanol was added 3.49 ml of triethylorthoacetate and the reaction refluxed for 6 hours. The solvent was removed and the residue partitioned between ethyl acetate and water. The organic phase was separated, dried and the solvent removed to give 2.87 g of product as a brown oil.

Aufarbeitung

  1. temperaturethe reaction refluxed for 6 hours
  2. customThe solvent was removed
  3. customthe residue partitioned between ethyl acetate and water
  4. customThe organic phase was separated
  5. customdried
  6. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-62923b89039e4f66ab900a6a4998885a
Quelldatensatz
uspto-grants-1988_11
Patentnummer
US04782050

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