HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
tert-Butyl methyl ether → 6-(cyclopentyloxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | tert-Butyl methyl ether | HCID 15413 | — |
| Edukt | 4-Phenylpiperidine | HCID 69873 | — |
| Edukt | Fumarate | HCID 5460307 | — |
| Edukt | 6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one | HCID 19927635 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Lösungsmittel | Isopropanol | HCID 3776 | — |
| Produkt | 6-(cyclopentyloxy)-7-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927691 | 48% |
Reaktionsschritte
Method B (30 h at 45° C.); starting materials: 6-(cyclo-pentyloxy)-7-[3-(methanesulfonyloxy)propoxy]-2H-1-benzopyran-2-one (example 72) and 4-phenylpiperidine; yield 48%; fusion point 96°-97° C. (from TBME and isopropanol). Fumarate: method E; yield 83%; fusion point 171°-173° C. (from acetone).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05428038 |
| Quelldatensatz | uspto-grants-1995_06 |
| ORD ID | ord-54f2a4b0bf734d449f00a8d39ca228b9 |
| Quellennotiz | uspto-grants-1995_06 |