Dimethylformamide → Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

HRID 2232645Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2232645
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C)C=O.S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([Cl:21])=[O:5]

Komponenten

4

Edukt 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 139380362,3-Dichloro-4,5-difluorobenzoic acid

Produkt 1

HCID 10999320Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

Versuchsvorschrift

A solution of 2,3-dichloro-4,5-difluorobenzoic acid (9.3 g) and dimethylformamide (0.013 ml) in thionyl chloride (40 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation in nitrogen atmosphere to give the title compound (8.7 g) as pale yellow oil, bp 123°-126° C./40 mmHg.

Aufarbeitung

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation in nitrogen atmosphere

Quellen und Nachweise

ORD-Eintrag
ord-ea06f8b905af4ef39127de398d3ba8e4
Quelldatensatz
uspto-grants-1988_11
Patentnummer
US04788320

Notizen zur Reaktion

Wird geladen…