Potassium Cyanide → HCID 68445800, Verbindung
Reaktionsgleichung
Br[CH2:2][C:3]1[C:4]([F:15])=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([O:13][CH3:14])[CH:9]=[N:8]2.[C-:16]#[N:17].[K+]>CN(C)C=O>[F:15][C:4]1[C:3]([CH2:2][C:16]#[N:17])=[C:12]2[C:7](=[CH:6][CH:5]=1)[N:8]=[CH:9][C:10]([O:13][CH3:14])=[N:11]2Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
A mixture of 8-bromomethyl-7-fluoro-2-(methyloxy)quinoxaline (5.89 g, 20 mmol) and potassium cyanide (3.2 g, 49 mmol) in dimethylformamide (125 ml) was heated at 50° C. for approx. 40 h. More potassium cyanide (0.8 g) was added and heating continued at 60° C. for ˜8 h. The mixture was then evaporated and the residue was dissolved in dichloromethane and washed with water. The aqueous phase was extracted twice with dichloromethane and the combined organic fractions were dried and evaporated. Chromatography on silica (300 g), eluting with 0-25% ethyl acetate/hexane gave product (2.47 g, 57%).