HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 3-Amino-4-fluorobutanoic acid hcl
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | 3-Boc-amino-4-fluorobutanoic acid | HCID 20508340 | — |
| Lösungsmittel | Diethyl Ether | HCID 3283 | — |
| Produkt | 3-Amino-4-fluorobutanoic acid hcl | HCID 86007272 | 68% |
Reaktionsschritte
4-Fluoro-3-tert-butoxycarbonylamino-1-butanoic acid (545 mg, 2.46 mmoles) is dissolved in dry ether (20 ml) saturated with hydrogen chloride gas. After a few minutes, the solution becomes turbid and white crystals start to precipitate. Recrystallization from ethanol by addition of diethylether affords 4-fluoro-3-amino-1-butanoic acid hydrochloride (265 mg, 68%), m.p. 152°-153° C. (dec).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04353828 |
| Quelldatensatz | uspto-grants-1982_10 |
| ORD ID | ord-4edc7ec33ded4ecbb062a1d2ef3af030 |
| Quellennotiz | uspto-grants-1982_10 |