HCID 59295921, Verbindung → 2-(Carboxymethyl)-4-fluorobenzoic acid
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:17]([O:19]C)=[O:18])=[C:6]([CH:8](C(OC)=O)[C:9]([O:11]C)=[O:10])[CH:7]=1>Cl>[C:9]([CH2:8][C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[C:17]([OH:19])=[O:18])([OH:11])=[O:10]Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 110 °C
Versuchsvorschrift
A suspension of dimethyl [5-fluoro-2-(methoxycarbonyl)phenyl]malonate (1.80 g) in concentrated hydrochloric acid (25 ml) was heated at 110° C. for 48 h. The reaction was cooled and the subtitle compound collected as a white solid by filtration (1.0 g).
Aufarbeitung
- temperatureThe reaction was cooled
- filtrationthe subtitle compound collected as a white solid by filtration (1.0 g)
Quellen und Nachweise
- ORD-Eintrag
- ord-2ca36af58f414a0ca311e19f37e4d677
- Quelldatensatz
- uspto-grants-2010_05
- Patentnummer
- US07709500B2
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