Hydrochloric Acid → HCID 59295961, Verbindung

HRID 2233397Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2233397
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[C:13]([O:15]C)=[O:14].[OH-].[Na+].Cl>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[C:13]([OH:15])=[O:14]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53429435Methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

Produkt 1

HCID 59295961HCID 59295961, VerbindungAusbeute 95,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate (1.3 g) in methanol (3 ml) was added a aqueous solution (3 ml) of sodium hydroxide (1 g) and the reaction mixture was heated at 80° C. for 3 h. The reaction was cooled to 20° C. and carefully acidified with concentrated hydrochloric acid. The white precipitate was isolated by filtration, washed with water and methanol to yield the title compound (1.16 g)

Aufarbeitung

  1. temperatureThe reaction was cooled to 20° C.
  2. customThe white precipitate was isolated by filtration
  3. washwashed with water and methanol

Quellen und Nachweise

ORD-Eintrag
ord-0868ada0a3724d0eac7566f608a05aaf
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709500B2

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