Triethylamine → 4-Amino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid, 1,1-dimethylethyl ester

HRID 2233743Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2233743
[CH3:1][C:2]([O:5][C:6](=[O:30])[CH2:7][N:8]1[C:16]2[C:11](=[C:12]([N+:18]([O-])=O)[CH:13]=[CH:14][C:15]=2Br)[C:10]([O:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)=[C:9]1[CH3:29])([CH3:4])[CH3:3].C(N(CC)CC)C>CCOC(C)=O.[Pt]>[NH2:18][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:11]=1[C:10]([O:21][C:22]1[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=1)=[C:9]([CH3:29])[N:8]2[CH2:7][C:6]([O:5][C:2]([CH3:3])([CH3:4])[CH3:1])=[O:30]

Komponenten

5

Edukt 2

HCID 8471TriethylamineHCID 686169457-Bromo-3-(4-chlorophenoxy)-2-methyl-4-nitro-1H-indole-1-acetic acid 1,1 dimethylethyl ester

Produkt 1

HCID 866092304-Amino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid, 1,1-dimethylethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of the product from step (iii) (0.18 g) in EtOAc (30 ml) was added triethylamine (0.15 ml) and 5% Pt/C (36 mg) and the reaction stirred under hydrogen (1 atm) for 2 h. The reaction was filtered through celite and the filtrate evaporated under reduced pressure. Yield 0.139 g.

Aufarbeitung

  1. filtrationThe reaction was filtered through celite
  2. customthe filtrate evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ed29568ca60e40dab39b8b97d8cce620
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709521B2

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