Hydrochloric Acid → HCID 68579996, Verbindung

HRID 2233805Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2233805
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)=[O:10].Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([CH3:8])[NH:4][C:3]=1[C:9]([NH:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)=[O:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68579743tert-Butyl 4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidine-1-carboxylate2×

Produkt 1

HCID 68579996HCID 68579996, VerbindungAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

tert-Butyl 4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidine-1-carboxylate (Intermediate 2, 1.978 g, 5.257 mol) was treated with 4 M HCl in dioxane (20 ml), and the reaction was stirred at room temperature for 1.5 h. The reaction mixture was concentrated under reduced pressure to give the desired material as a pink solid (1.61 g, 98% yield).

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-eaebfcef7e5a4b1fbb8196b5bf84e440
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07709503B2

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