4-Chloro-5-methyl-1H-pyrrole-2-carboxylic acid → 4-Bromo-5-ethyl-1H-pyrrole-2-carboxylic acid

Reaktionsgleichung

[Br:1][C:2]1[CH:3]=[C:4]([C:9]([O:11]CC)=[O:10])[NH:5][C:6]=1[CH2:7][CH3:8].ClC1C=C(C(O)=O)NC=1C>>[Br:1][C:2]1[CH:3]=[C:4]([C:9]([OH:11])=[O:10])[NH:5][C:6]=1[CH2:7][CH3:8]

Komponenten

Edukt 2

HCID 251376814-Chloro-5-methyl-1H-pyrrole-2-carboxylic acid

HCID 68580112ethyl 4-bromo-5-ethyl-1H-pyrrole-2-carboxylate2×

Produkt 1

HCID 685798234-Bromo-5-ethyl-1H-pyrrole-2-carboxylic acid

Versuchsvorschrift

This intermediate was synthesized from ethyl 4-bromo-5-ethyl-1H-pyrrole-2-carboxylate (Intermediate 11) by an analogous method to Intermediate 8.

Quellen und Nachweise

ORD-Eintrag: ord-0adce7c1ae92448ea266bb079c8ce6bd
Quelldatensatz: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07709503B2

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