Methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6-chloroisonicotinate → Methyl 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinate hydrochloride salt
Reaktionsgleichung
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:16]=[C:17]([CH:22]=[C:23]([Cl:25])[N:24]=2)[C:18]([O:20][CH3:21])=[O:19])[CH2:11][CH2:10]1)=O)(C)(C)C>Cl.O1CCOCC1>[ClH:25].[NH2:8][CH:9]1[CH2:10][CH2:11][N:12]([C:15]2[CH:16]=[C:17]([CH:22]=[C:23]([Cl:25])[N:24]=2)[C:18]([O:20][CH3:21])=[O:19])[CH2:13][CH2:14]1Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Methyl 2-{4-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-6-chloroisonicotinate (Intermediate 23, 1.81 g, 4.9 mmol) was dissolved in 4 N HCl/dioxane (200 ml). The mixture was stirred at room temperature for 2 h. The solvent was removed under vacuum to give the title compound (1.5 g).