Methylacrylamide → 3-(Sec-butylamino)-N-methylpropanamide

Temperatur

140 °C

A mixture of N-methylacrylamide (ABCR; 500 mg, 5.87 mmol), sec-butylamine (Aldrich; 530 mL, 5.22 mmol) and ethanol (4 mL) was heated in a microwave to 140° C. for 45 minutes and then at 150° C. for 30 minutes. The reaction mixture was cooled and poured onto an SCX-2 cartridge (5 g) and cartridge washed through with methanol (˜50 mL). Products were then eluted with 2M ammonia in methanol (˜50 mL) and evaporated to afford the title compound as a straw coloured oil (563 mg; 61%)

1. temperatureThe reaction mixture was cooled
2. additionpoured onto an SCX-2 cartridge (5 g) and cartridge
3. washwashed through with methanol (˜50 mL)
4. washProducts were then eluted with 2M ammonia in methanol (˜50 mL)
5. customevaporated

ORD-Eintrag

ord-f376d88a2dd4488192f61fa516534766

Quelldatensatz

uspto-grants-2010_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07709471B2