HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(4-Fluorophenyl)piperazine → 8-{3-[4-(4-fluorophenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(4-Fluorophenyl)piperazine | HCID 75260 | — |
| Edukt | Fumarate | HCID 5460307 | — |
| Edukt | 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one | HCID 19927662 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 8-{3-[4-(4-fluorophenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927713 | 84% |
Reaktionsschritte
Method B (12 h at 55° C.); starting materials: 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 82) and 1-(4-fluorophenyl)piperazine; yield 84%; fusion point 139°-141° C. (from ethanol). Fumarate: method E; yield 90%; fusion point 195°-200° C. (from ethanol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05428038 |
| Quelldatensatz | uspto-grants-1995_06 |
| ORD ID | ord-a9cd8dfe7fff459989a271e227763bd8 |
| Quellennotiz | uspto-grants-1995_06 |