Sodium Carbonate → N-acryloylalanine ethyl ester

HRID 223525Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 223525
Cl.[CH2:2]([O:4][C:5](=[O:9])[C@H:6]([CH3:8])[NH2:7])[CH3:3].[C:10](Cl)(=[O:13])[CH:11]=[CH2:12].C(=O)([O-])[O-].[Na+].[Na+]>C1C=CC=CC=1>[CH2:2]([O:4][C:5](=[O:9])[C@H:6]([CH3:8])[NH:7][C:10](=[O:13])[CH:11]=[CH2:12])[CH3:3]

Komponenten

5

Edukt 3

HCID 10340Sodium CarbonateHCID 13140Acryloyl chlorideHCID 2724356L-Alanine, ethyl ester, hydrochloride (1:1)

Produkt 1

HCID 54390476N-acryloylalanine ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To 0.5 moles of alanine ethyl ester hydrochloride in 500 ml. of benzene is added 0.5 moles of acryloyl chloride. To this stirred mixture is added portionwise 0.6 moles of anhydrous sodium carbonate. The reaction mixture is then refluxed for 1 hour, stirred an additional 2 hours, filtered, and the filtrate concentrated to give N-acryloylalanine ethyl ester.

Aufarbeitung

  1. temperatureThe reaction mixture is then refluxed for 1 hour
  2. filtrationfiltered
  3. concentrationthe filtrate concentrated

Quellen und Nachweise

ORD-Eintrag
ord-8632107f4d314dad84b39381690d12a8
Quelldatensatz
uspto-grants-1982_10
Patentnummer
US04355034

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