Tetrahydrofuran → N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide

HRID 2235402Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2235402
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[N:7]([CH2:14][C:15]#[C:16][CH2:17][CH3:18])[C:6](=[O:19])[C:5]2([CH3:21])[CH3:20].[CH2:22]1[CH2:26][O:25][CH2:24][CH2:23]1>>[CH3:21][C:5]1([CH3:20])[C:4]2[C:8](=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:2]([NH:1][C:24](=[O:25])[CH2:23][CH2:22][C:26]3[CH:4]=[CH:3][CH:2]=[CH:10][CH:9]=3)[CH:3]=2)[N:7]([CH2:14][C:15]#[C:16][CH2:17][CH3:18])[C:6]1=[O:19]

Komponenten

3

Edukt 2

HCID 8028TetrahydrofuranHCID 593009855-Amino-3,3-dimethyl-6-nitro-1-(pent-2-ynyl)-1,3-dihydro-indol-2-one

Produkt 1

HCID 67427209N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide

Versuchsvorschrift

N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide is prepared as described in Example 25a starting from A7 (73 mg) using THF (3 ml) as solvent. The crude material (106 mg) is used without further purification.

Aufarbeitung

  1. customThe crude material (106 mg) is used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-41c4b5ce1c1147e7941f9fdc4c58253e
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07714010B2

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