2-Morpholin-4-yl-7-nitro-1,3-benzothiazole → 2-Morpholin-4-yl-1,3-benzothiazol-7-amine

HRID 2235495Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2235495
[N:1]1([C:7]2[S:8][C:9]3[C:15]([N+:16]([O-])=O)=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>O1CCCC1.[Ni]>[N:1]1([C:7]2[S:8][C:9]3[C:15]([NH2:16])=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Komponenten

4

Edukt 1

HCID 685822692-Morpholin-4-yl-7-nitro-1,3-benzothiazole

Produkt 1

HCID 685811022-Morpholin-4-yl-1,3-benzothiazol-7-amineAusbeute 33,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To 0.075 g (0.28 mmol) of 2-morpholin-4-yl-7-nitro-1,3-benzothiazole in 6 mL of tetrahydrofuran (THF) was added a pipet tip of Raney nickel. The reaction was kept under a hydrogen atmosphere via a balloon and stirred at room temperature for 5 h. The catalyst was removed via filtration and the filtrate was concentrated in vacuo. Purification by flash chromatography failed to provide clean B so the 0.022 g (33%) of material thus isolated was used without further purification.

Aufarbeitung

  1. customThe catalyst was removed via filtration
  2. concentrationthe filtrate was concentrated in vacuo
  3. customPurification by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e473b00148bf452999d211fc4779340e
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07714009B2

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