Hydrochloric Acid → 3-Methoxy-4-(prop-2-ynyloxy)benzoic acid

HRID 2236366Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236366
[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([O:11]CC#C)=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3].[OH-].[Na+].Cl>CO>[CH2:1]([O:4][C:5]1[CH:16]=[CH:15][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[O:17][CH3:18])[C:2]#[CH:3]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 593017652-Propynyl 4-(2-propynyloxy)-3-methoxybenzoate

Produkt 1

HCID 131214803-Methoxy-4-(prop-2-ynyloxy)benzoic acidAusbeute 107,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To 50 ml of methanol were added 13.2 g of 2-propynyl 4-(2-propynyloxy)-3-methoxybenzoate and 40 ml of 15% aqueous sodium hydroxide solution and the mixture obtained was stirred at room temperature for 8 hours and at 50° C. for 2 hours. Then, the reaction mixture was added to hydrochloric acid for acidification. Crystals precipitated were collected by filtration and dried to obtain 12.0 g of 4-(2-propynyloxy)-3-methoxybenzoic acid represented by the formula:

Aufarbeitung

  1. customthe mixture obtained
  2. customCrystals precipitated
  3. filtrationwere collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-95fa9f52a0284dd3b043d2312caf63eb
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07714168B2

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