Sodium Azide → 2-Azidomethyl-5-propoxy-pyridin-4-ol

HRID 2236539Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236539
[N-:1]=[N+:2]=[N-:3].[Na+].Cl[CH2:6][C:7]1[CH:12]=[C:11]([OH:13])[C:10]([O:14][CH2:15][CH2:16][CH3:17])=[CH:9][N:8]=1>CN(C)C=O>[N:1]([CH2:6][C:7]1[CH:12]=[C:11]([OH:13])[C:10]([O:14][CH2:15][CH2:16][CH3:17])=[CH:9][N:8]=1)=[N+:2]=[N-:3]

Komponenten

4

Edukt 2

HCID 33557Sodium AzideHCID 178458779HCID 178458779, Verbindung

Produkt 1

HCID 1784587892-Azidomethyl-5-propoxy-pyridin-4-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a suspension of sodium azide (2.82 g, 43.3 mmole) in 30 mL of N,N-dimethylformamide is added 2-chloromethyl-5-propoxy-pyridin-4-ol (8.74 g, 43.3 mmole). This is stirred for overnight at ambient temperature then quenched into ice water. The solid formed is filtered, washed with cold water and dried to give an off white solid, 5.74 g, (63%); MS (ES+): m/z 209.3 (M+H).

Aufarbeitung

  1. customthen quenched into ice water
  2. customThe solid formed
  3. filtrationis filtered
  4. washwashed with cold water
  5. customdried
  6. customto give an off white solid, 5.74 g, (63%)

Quellen und Nachweise

ORD-Eintrag
ord-67ed3b4eb1544676b1725ced3ff6a336
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713994B2

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