Triethylamine → HCID 178491077, Verbindung

HRID 2236658Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236658
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]/OC.Cl.[F:18][C:19]1[CH:20]=[C:21]([CH:24]=[CH:25][C:26]=1[O:27][CH3:28])[CH2:22][NH2:23].C(N(CC)CC)C>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\[NH:23][CH2:22][C:21]1[CH:24]=[CH:25][C:26]([O:27][CH3:28])=[C:19]([F:18])[CH:20]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 224674033-Fluoro-4-MethoxybenzylaMineHClHCID 68692760(E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

Produkt 1

HCID 178491077HCID 178491077, VerbindungAusbeute 69,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (0.11 g, 0.39 mmol) and 3-fluoro-4-methoxy-benzylamine hydrochloride (75 mg, 0.39 mmol) in tetrahydrofuran (5 mL) is added triethylamine (0.13 mL, 0.98 mmol). After 15 minutes of stirring, the solvent is evaporated under reduced pressure. The solid material is collected by Buchner filtration, washed successively with diethyl ether, water, and methanol, and then dried under house vacuum to give (4Z)-6-bromo-4-{[(3-fluoro-4-methoxybenzyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione as an off-white solid (0.11 g, 69%).

Aufarbeitung

  1. customthe solvent is evaporated under reduced pressure
  2. filtrationThe solid material is collected by Buchner filtration
  3. washwashed successively with diethyl ether, water, and methanol
  4. customdried under house vacuum

Quellen und Nachweise

ORD-Eintrag
ord-830bcfec633b462e93f018e3782ea4b1
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713994B2

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