3-Hydroxy-4-phenylbenzylamine → HCID 178518360, Verbindung

HRID 2236862Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236862
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([OH:15])[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][CH:8]=1.[I:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23](=[O:27])[NH:22][C:21](=[O:28])[C:20]2=[CH:29]OC>CN(C)C=O>[OH:15][C:5]1[CH:4]=[C:3]([CH2:2][NH:1][CH:29]=[C:20]2[C:19]3[C:24](=[CH:25][CH:26]=[C:17]([I:16])[CH:18]=3)[C:23](=[O:27])[NH:22][C:21]2=[O:28])[CH:8]=[CH:7][C:6]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

4

Edukt 2

HCID 231438563-Hydroxy-4-phenylbenzylamineHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione

Produkt 1

HCID 178518360HCID 178518360, VerbindungAusbeute 89,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-Aminomethyl-biphenyl-2-ol (80 mg, 0.4 mmol) and 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (110 mg, 0.34 mmol) is stirred in N,N-dimethylformamide (5 mL). After which N,N-dimethylformamide is removed under vacuum and the residue is triturated with MeOH. The precipitate thus formed is collected and washed with MeOH and dried to provide the title compound (151 mg, 89%). MS (ESI): 495.1 (M−1)−1.

Aufarbeitung

  1. customAfter which N,N-dimethylformamide is removed under vacuum
  2. customthe residue is triturated with MeOH
  3. customThe precipitate thus formed
  4. customis collected
  5. washwashed with MeOH
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-dae6d350212d43ed91dae3eabd769649
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713994B2

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