(4E)-6-t-butyl-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione → HCID 178458786, Verbindung

HRID 2236895Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236895
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][C:9](=[O:16])/[C:8]/2=[CH:17]/OC)([CH3:4])([CH3:3])[CH3:2].[NH2:20][CH2:21][C:22]1[CH:27]=[C:26]([OH:28])[C:25]([O:29][CH2:30][CH2:31][CH3:32])=[CH:24][N:23]=1>CN(C)C=O>[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][C:9](=[O:16])[C:8]2=[CH:17][NH:20][CH2:21][C:22]1[CH:27]=[C:26]([OH:28])[C:25]([O:29][CH2:30][CH2:31][CH3:32])=[CH:24][N:23]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 42625173(4E)-6-t-butyl-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dioneHCID 178458783HCID 178458783, Verbindung

Produkt 1

HCID 178458786HCID 178458786, VerbindungAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

An amount of 50.0 mg (0.193 mmol) of (4E)-6-tert-butyl-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione, is dissolved in N,N-dimethylformamide (3 mL), followed by the addition of 35 mg (0.193 mmol) of 2-aminomethyl-5-propoxy-pyridin-4-ol. All solids dissolved and after the mixture is stirred at room temperature for 2 hours, the solution is evaporated to dryness in vacuo, treated with acetonitrile, filtered and washed several times with fresh acetonitrile and dried to give 52 mg of the title compound as a light pink solid (66% yield); mp 162-178° C. dec, MS data ES(+) 410.4 m/e.

Aufarbeitung

  1. dissolutionAll solids dissolved
  2. customthe solution is evaporated to dryness in vacuo
  3. additiontreated with acetonitrile
  4. filtrationfiltered
  5. washwashed several times with fresh acetonitrile
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c286da46e3254da3af024ab6b5daa07c
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713994B2

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