5-Aminomethyl-2-furan-3-yl-phenol → HCID 178518297, Verbindung
Reaktionsgleichung
OC1C=C(CNC=C2C3C(=CC=C(I)C=3)C(=O)NC2=O)C=CC=1C1C=CC=CC=1.[CH:30]1([C:35]2[CH:36]=[C:37]3[C:42](=[CH:43][CH:44]=2)[C:41](=[O:45])[NH:40][C:39](=[O:46])[C:38]3=[CH:47]OC)[CH2:34][CH2:33][CH2:32][CH2:31]1.[NH2:50][CH2:51][C:52]1[CH:53]=[CH:54][C:55]([C:59]2[CH:63]=[CH:62][O:61][CH:60]=2)=[C:56]([OH:58])[CH:57]=1>>[CH:30]1([C:35]2[CH:36]=[C:37]3[C:42](=[CH:43][CH:44]=2)[C:41](=[O:45])[NH:40][C:39](=[O:46])[C:38]3=[CH:47][NH:50][CH2:51][C:52]2[CH:53]=[CH:54][C:55]([C:59]3[CH:63]=[CH:62][O:61][CH:60]=3)=[C:56]([OH:58])[CH:57]=2)[CH2:31][CH2:32][CH2:33][CH2:34]1Komponenten
4
Versuchsvorschrift
Following the same procedure for the preparation of 4-{[(2-hydroxy-biphenyl-4-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione, the title compound (purified through chromatography) is prepared from 6-cyclopentyl-4-methoxymethylene-4H-isoquinoline-1,3-dione (108 mg, 0.398 mmol) and 5-Aminomethyl-2-furan-3-yl-phenol (109 mg, 0.57 mmol) in 78% yield: MS (ESI): 427.1 (M−1)−1.