Hydrazine → N-(4-aminobenzyl)ethanesulfonamide

HRID 2236928Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2236928
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][NH:9][S:10]([CH2:13][CH3:14])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-])=O.NN>[Ni].CO>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][NH:9][S:10]([CH2:13][CH3:14])(=[O:12])=[O:11])=[CH:6][CH:5]=1

Komponenten

5

Edukt 2

HCID 9321HydrazineHCID 47372696N-(4-nitrobenzyl)ethanesulfonamide

Produkt 1

HCID 39243426N-(4-aminobenzyl)ethanesulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To the residue of the product from step 1 (0.25 mmol) is added methanol (350 μL), hydrazine (33 μL), and Raney-Nickel (10 mg). The reaction mixture is shaken at room temperature for 16 hours, then filtered and the solution concentrated to yield ethanesulfonic acid 4-amino-benzylamide, which is used as such for the subsequent reaction.

Aufarbeitung

  1. filtrationfiltered
  2. concentrationthe solution concentrated

Quellen und Nachweise

ORD-Eintrag
ord-56f987b31f4c49e5bdcb88db96800530
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07713994B2

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