4-Chloropyridine → [2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4-Chloropyridine	HCID 12288	—
Edukt	2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine	HCID 59699242	—
Lösungsmittel	Dimethylformamide	HCID 6228	—
Produkt	[2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethyl]-pyridin-4-yl-amine	HCID 59699105	—

Reaktionsbedingungen

Temperatur	100 °C

Reaktionsschritte

2-(4-{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}-phenoxy)-ethylamine, the product of Example 512, was treated with 4-chloropyridine in DMF and was heated at 100° C. Aqueous workup and chromatography on silica gel afforded Example 519. (Yield: 80 mg)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07714013B2
Quelldatensatz	uspto-grants-2010_05
ORD ID	ord-5013b07f9c154b3fadfc49efd5d9de02
Quellennotiz	uspto-grants-2010_05