1-[2-(Acetylthio)-1-oxoethyl]-4-[(2-furyl)methyl]-4-hydroxy-L-proline → 4-[(2-furyl)methyl]-4-hydroxy-L-proline
Reaktionsgleichung
C([N:11]1[CH2:18][C:17]([CH2:20][C:21]2[O:22][CH:23]=[CH:24][CH:25]=2)([OH:19])[CH2:16][C@H:12]1[C:13]([OH:15])=[O:14])(OCC1C=CC=CC=1)=O.C(SCC(N1CC(CC2OC=CC=2)(O)C[C@H]1C(O)=O)=O)(=O)C>>[O:22]1[CH:23]=[CH:24][CH:25]=[C:21]1[CH2:20][C:17]1([OH:19])[CH2:18][NH:11][C@H:12]([C:13]([OH:15])=[O:14])[CH2:16]1Komponenten
3
Versuchsvorschrift
The N-carbobenzyloxy-4-[(2-furyl)methyl]-4-hydroxy-L-proline from part (a) is hydrogenated according to the procedure of Example 1 (b) to yield 4-[(2-furyl)methyl]-4-hydroxy-L-proline. This amino acid is reacted with 2-acetylthioacetyl chloride according to the procedure of Example 1 (c) to yield 1-[2-(acetylthio)-1-oxoethyl]-4-[(2-furyl)methyl]-4-hydroxy-L-proline.
Quellen und Nachweise
- ORD-Eintrag
- ord-6f3d0f8ebbf640878818e697dc27e1b2