[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid	HCID 677042	—
Edukt	N,N-dimethyl-2-(piperazin-1-yl)acetamide	HCID 2758642	—
Produkt	4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide	HCID 59698886	—

Reaktionsschritte

In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with piperazino-acetic acid N,N-dimethylamide to give 4-chloro-N-{4-[2-(4-dimethylcarbamoylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide, using general procedure A. Amorphous white solid. MS 450.0 ([M+H]+)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07718659B2
Quelldatensatz	uspto-grants-2010_05
ORD ID	ord-474ae8bc825142ccab7d75fd90c53d4c
Quellennotiz	uspto-grants-2010_05