Sodium Hydroxide → (2S)-1-methyl-5-oxopyrrolidine-2-carboxylic acid

Temperatur

0 °C

Ethyl 1-methyl-5-oxoprolinate (0.27 g, 1.58 mmol) was dissolved in ethanol (5 ml) and cooled to 0° C. in an ice bath. To this was added 2M aqueous sodium hydroxide solution (3 ml) and the mixture was stirred for ˜4 hours at 0° C. The ethanol was evaporated under vacuum and the aqueous residue was acidified with 2N aqueous hydrogen chloride to pH1. The volume of the aqueous phase was reduced to ˜3 ml under vacuum and then extracted with a 3:1 mixture of chloroform and isopropanol using a phase separator. The combined organic layers were concentrated to give 1-methyl-5-oxoproline which was used without further purification.

1. customThe ethanol was evaporated under vacuum
2. extractionextracted with a 3:1 mixture of chloroform and isopropanol using a phase separator
3. concentrationThe combined organic layers were concentrated

ORD-Eintrag

ord-28bbfc59df2c4c4395c4f787f1fda792

Quelldatensatz

uspto-grants-2010_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07718693B2