1-{Imidazo[1,2-a]pyridin-3-yl}ethan-1-one → HCID 59176797, Verbindung

HRID 2238630Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2238630
[N:1]1[CH:2]=[C:3]([C:10](=[O:12])[CH3:11])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12>COC(OC)N(C)C>[CH3:3][N:4]([CH3:9])/[CH:5]=[CH:11]/[C:10]([C:3]1[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]2=[N:1][CH:2]=1)=[O:12]

Komponenten

3

Edukt 1

HCID 157181821-{Imidazo[1,2-a]pyridin-3-yl}ethan-1-one

Produkt 1

HCID 59176797HCID 59176797, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 78373Dimethylformamide dimethyl acetalLösungsmittel

Versuchsvorschrift

Unpurified imidazo[1,2-a]pyridin-3-ylethanone [1-1] was dissolved in 400 mL of N,N-dimethylformamide dimethylacetal, and overheated overnight under reflux. The dimethylformamide dimethylacetal was distilled off under reduced pressure, and then diethyl ether was added to the residue. Thus obtained solid was separated by filtration and dried under reduced pressure, to obtain 5.06 g of (E)-3-(dimethylamino)-1-imidazo[1,2-a]pyridin-3-yl-2-propen-1-one [1-2] as a light brown solid.

Aufarbeitung

  1. temperatureoverheated overnight under reflux
  2. distillationThe dimethylformamide dimethylacetal was distilled off under reduced pressure
  3. additiondiethyl ether was added to the residue
  4. customThus obtained solid was separated by filtration
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-938b73aebbd24a2eaaab8319abce0f70
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07718801B2

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