Hydrochloride methanol → Methyl 3-cyclopropylpyridine-2-carboxylate

HRID 2238670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2238670
[CH:1]1([C:4]2[C:5]([C:10]([OH:12])=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:3][CH2:2]1.Cl.[CH3:14]O>>[CH:1]1([C:4]2[C:5]([C:10]([O:12][CH3:14])=[O:11])=[N:6][CH:7]=[CH:8][CH:9]=2)[CH2:2][CH2:3]1

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 686851453-Cyclopropylpicolinic acid

Produkt 1

HCID 68687300Methyl 3-cyclopropylpyridine-2-carboxylate

Versuchsvorschrift

830 mg of a hydrochloride salt of the 3-cyclopropylpyridine-2-carboxylic acid [121-3] was dissolved in 100 mL of 10% hydrochloric acid-methanol solution, and heated overnight under reflux. The reaction solution was concentrated under reduced pressure, a saturated aqueous solution of sodium hydrogen carbonate was added to the obtained residue, and was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous sodium sulfate. The insolubles were filtered, the filtrate was concentrated under reduced pressure, and 363 mg of methyl 3-cyclopropylpyridine-2-carboxylate [121-4] was obtained as a white solid.

Aufarbeitung

  1. temperatureheated overnight
  2. temperatureunder reflux
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. additiona saturated aqueous solution of sodium hydrogen carbonate was added to the obtained residue
  5. extractionwas extracted with ethyl acetate
  6. washThe organic layer was washed with saturated brine
  7. dry with materialdried over anhydrous sodium sulfate
  8. filtrationThe insolubles were filtered
  9. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-35cad4f5ba5e4f2885be1ebfb664c756
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07718801B2

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