2-Morpholinoethylamine → HCID 11639781, Verbindung
Reaktionsgleichung
[CH2:1]([N:5]1[C:9](=[O:10])[C:8](Cl)=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[S:6]1(=[O:19])=[O:18])[CH2:2][CH2:3][CH3:4].[N:20]1([CH2:26][CH2:27][NH2:28])[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>>[CH2:1]([N:5]1[C:9](=[O:10])[C:8]([NH:28][CH2:27][CH2:26][N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)=[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[S:6]1(=[O:19])=[O:18])[CH2:2][CH2:3][CH3:4]Komponenten
3
Versuchsvorschrift
The title compound was prepared from 2-butyl-4-chloro-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 2-morpholin-4-ylethanamine in a similar manner as described for e.g. Example 6 and 7. 1H NMR (500 MHz CDCl3): δ 7.58-7.50 (m, 2H), 7.50-7.00 (m, 3H), 6.05 (t, 1H), 3.78-3.65 (m, 6H), 2.92-2.88 (m, 2H), 2.46-2.32 (m, 6H), 1.88-1.80 (m, 2H), 1.50-1.42 (m, 2H), 1.00 (t, 3H); 13C NMR (125 MHz CDCl3): δ 159.2, 135.9, 131.6, 129.8, 128.9, 125.3, 107.2, 67.1, 56.4, 53.2, 40.3, 40.2, 30.5, 20.3, 13.8; Mass Spectrum: M+H+ 394.
Quellen und Nachweise
- ORD-Eintrag
- ord-163e9503f58b4d348041f8342bad9117
- Quelldatensatz
- uspto-grants-2010_05