1-Benzyl-4-(4-fluoro-2-nitrophenylamino)-piperidine → 1-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidine

HRID 2240277Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240277
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[N+:22]([O-])=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.CO.[Pt]>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[NH2:22])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 212627651-Benzyl-4-(4-fluoro-2-nitrophenylamino)-piperidine

Produkt 1

HCID 211930651-Benzyl-4-(2-amino-4-fluorophenylamino)-piperidineAusbeute 99,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

1-Benzyl-4-(4-fluoro-2-nitrophenylamino)-piperidine (10.1 g) were dissolved in 1:1 THF-methanol (150 ml) and hydrogenated with Pt/C (1.5 g, 10%) at room temperature for 1.5 h. The catalyst was then removed by filtration, and the filtrate evaporated to yield 9.1 g of the title compound as an oil. The compound was used without further purification.

Aufarbeitung

  1. customThe catalyst was then removed by filtration
  2. customthe filtrate evaporated

Quellen und Nachweise

ORD-Eintrag
ord-a8a59923bae44793aa6ac70f1b82693d
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723360B2

Notizen zur Reaktion

Wird geladen…