2,3-Bis(trifluoromethyl)aniline → 1-(2,3-Bis(trifluoromethyl)phenyl)-3-(2-fluoropyridin-3-ylmethyl)thiourea

HRID 2240447Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240447
[F:1][C:2]([F:15])([F:14])[C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[NH2:13].[F:16][C:17]1[C:22]([CH2:23][NH2:24])=[CH:21][CH:20]=[CH:19][N:18]=1.ClC1C(Cl)=CC=CC1(N=[C:35]=[S:36])F>>[F:1][C:2]([F:14])([F:15])[C:3]1[C:8]([C:9]([F:11])([F:12])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[NH:13][C:35]([NH:24][CH2:23][C:22]1[C:17]([F:16])=[N:18][CH:19]=[CH:20][CH:21]=1)=[S:36]

Komponenten

4

Edukt 3

HCID 199806622,3-Bis(trifluoromethyl)anilineHCID 45079719(2-Fluoropyridin-3-yl)methanamineHCID 866035332,3-Dichloro-1-fluorophenylisothiocyanate

Produkt 1

HCID 866035321-(2,3-Bis(trifluoromethyl)phenyl)-3-(2-fluoropyridin-3-ylmethyl)thioureaAusbeute 90 %

Versuchsvorschrift

Prepared in 90% yield from the product of Example 197A and the product of Example 193C according to the procedure described for the product of Example 192D and Example 192G.

Quellen und Nachweise

ORD-Eintrag
ord-afb3e0b2b3cb4d18a5991c57bb08e3b4
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723367B2

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