Sodium Hydroxide → HCID 68480823, Verbindung

HRID 2240555Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240555
[OH-].[Na+:2].ClC1C=CC(S(C2C3C(=CC=C(C)C=3)N(CC(O)=O)C=2C)(=O)=O)=CC=1.[Cl:28][C:29]1[C:30](C#N)=[C:31]2[C:35](=[CH:36][CH:37]=1)[N:34]([CH2:38][C:39]([O:41]C)=[O:40])[C:33]([CH3:43])=[C:32]2[S:44]([C:47]1[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=1)(=[O:46])=[O:45]>C1COCC1>[Cl:28][C:29]1[CH:30]=[C:31]2[C:35](=[CH:36][CH:37]=1)[N:34]([CH2:38][C:39]([O-:41])=[O:40])[C:33]([CH3:43])=[C:32]2[S:44]([C:47]1[CH:52]=[CH:51][C:50]([Cl:53])=[CH:49][CH:48]=1)(=[O:45])=[O:46].[Na+:2]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 104072752-[3-(4-chlorophenyl)sulfonyl-2,5-dimethylindol-1-yl]acetic acidHCID 86605157HCID 86605157, Verbindung

Produkt 1

HCID 68480823HCID 68480823, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Sodium hydroxide (1M, 4.3 ml) was added to a solution of the product of example 1 part (c) (1.75 g) in THF (60 ml). The reaction mixture was stirred overnight and then concentrated in vacuo. The residue was recrystallised from water to give the title compound as a white solid.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. customThe residue was recrystallised from water

Quellen und Nachweise

ORD-Eintrag
ord-649e2d82c664437ca5b7fcb7cb8878f8
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723373B2

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