Ethanol → HCID 16112965, Verbindung

HRID 2240926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2240926
[F:1][CH:2]([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15](O)C=2)=O)=[CH:6][CH:5]=1.Cl.[CH3:23][NH:24][C:25]([NH2:27])=[NH:26].[C:28](=[O:31])([O-])[O-].[Na+].[Na+].C([OH:36])C>>[NH2:26][C:25]1[N:24]([CH3:23])[C:28](=[O:31])[C:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][CH:2]([F:1])[F:21])=[CH:9][CH:8]=2)([C:11]2[CH:13]=[CH:18][CH:17]=[C:16]([OH:36])[CH:15]=2)[N:27]=1

Komponenten

5

Edukt 4

HCID 702EthanolHCID 10340Sodium CarbonateHCID 59790334HCID 59790334, VerbindungHCID 178485118HCID 178485118, Verbindung

Produkt 1

HCID 16112965HCID 16112965, VerbindungAusbeute 64 %

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

1-(4-(difluoromethoxy)phenyl)-2-(3-hydroxyphenyl)ethane-1,2-dione (0.11 g, 0.38 mmol) was dissolved in ethanol (5 mL). Methylguanidine hydrochloride (0.052 g, 0.47 mmol) was added followed by sodium carbonate (0.050 g, 0.47 mmol). The mixture was stirred at 85° C. overnight 15 hours. The solvent was removed and the material is absorbed onto celite. Purification by flash chromatography afforded 2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-hydroxyphenyl)-1-methyl-1H-imidazol-5(4H)-one (0.085 g, 64%).

Aufarbeitung

  1. customThe solvent was removed
  2. customthe material is absorbed onto celite
  3. customPurification by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-b977d5e6c5ba49fbbd2421b3273dbf91
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723368B2

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