4-Chloro-5-fluoro-1,2-phenylenediamine → 5-Chloro-2-[3-chloro-4-(3-piperazin-1-yl-propoxy)-phenyl]-6-fluoro-1H-benzoimidazole

HRID 2241764

Reaktionsgleichung

Reaktionsgleichung von HRID 2241764
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[NH:28][C:27]4[CH:29]=[C:30]([F:34])[C:31]([Cl:33])=[CH:32][C:26]=4[N:25]=3)=[CH:20][C:19]=2[Cl:35])[CH2:10][CH2:9]1)=O)(C)(C)C.C(OC(N1CCN(CCCOC2C=CC(C=O)=CC=2Cl)CC1)=O)(C)(C)C.ClC1C=C(N)C(N)=CC=1F>>[Cl:33][C:31]1[C:30]([F:34])=[CH:29][C:27]2[NH:28][C:24]([C:21]3[CH:22]=[CH:23][C:18]([O:17][CH2:16][CH2:15][CH2:14][N:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)=[C:19]([Cl:35])[CH:20]=3)=[N:25][C:26]=2[CH:32]=1

Komponenten

4

Edukt 3

HCID 7357734-Chloro-5-fluoro-1,2-phenylenediamineHCID 575254314-{3-[2-Chloro-4-(5-chloro-6-fluoro-1H-benzoimidazol-2-yl)-phenoxy]-propyl}-piperazine-1-carboxylic acid tert-butyl esterHCID 575254324-[3-(2-Chloro-4-formyl-phenoxy)-propyl]-piperazine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 113161825-Chloro-2-[3-chloro-4-(3-piperazin-1-yl-propoxy)-phenyl]-6-fluoro-1H-benzoimidazoleAusbeute 15 %

Versuchsvorschrift

4-{3-[2-Chloro-4-(5-chloro-6-fluoro-1H-benzoimidazol-2-yl)-phenoxy]-propyl}-piperazine-1-carboxylic acid tert-butyl ester. This compound was prepared by the method described in Example 1, using 4-[3-(2-chloro-4-formyl-phenoxy)-propyl]-piperazine-1-carboxylic acid tert-butyl ester (1.0 g, 2.6 mmol, 1.0 equiv), 4-chloro-5-fluoro-benzene-1,2-diamine (421 mg, 2.6 mmol, 1.0 equiv), and Na2S2O5 (648 mg, 3.4 mmol, 1.3 equiv) in General Procedure 3. Purification by Method 2 afforded 256 mg (15%) of the title compound. MS (electrospray): mass calculated for C25H29Cl2FN4O3, 522.16; m/z found, 545.3 [M+Na]+. B. 5-Chloro-2-[3-chloro-4-(3-piperazin-1-yl-propoxy)-phenyl]-6-fluoro-1H-benzoimidazole. To a suspension of 4-{3-[2-chloro-4-(5-chloro-6-fluoro-1H-benzoimidazol-2-yl)-phenoxy]-propyl}-piperazine-1-carboxylic acid tert-butyl ester (52.7 mg, 0.10 mmol) in dichloromethane (1.0 mL) at rt was added TFA (1.0 mL), and the reaction mixture was stirred for 50 min. The mixture was concentrated under reduced pressure, and the solid residue was washed four times with dichloromethane. The title compound was obtained in quantitative yield as the TFA salt. MS (electrospray): mass calculated for C20H21Cl2FN4O, 422.11; m/z found, 423.2 [M+H]+. 1H NMR (400 MHz, CD3OD): 8.17 (d, J=2.3 Hz, 1H), 8.03 (dd, J=8.7, 2.3 Hz, 1H), 7.81 (d, J=6.4 Hz, 1H), 7.59 (d, J=8.7 Hz, 1H), 7.36 (d, J=8.8 Hz, 1H), 4.33 (t, J=5.8 Hz, 2H), 3.50-3.47 (m, 4H), 3.36 (br s, 4H), 3.25 (t, J=7.4 Hz, 2H), 2.33-2.26 (m, 2H).

Aufarbeitung

  1. customThis compound was prepared by the method
  2. customPurification by Method 2

Quellen und Nachweise

ORD-Eintrag
ord-8b3c155ce6cc44969f0e39ceea16dd41
Quelldatensatz
uspto-grants-2010_05
Patentnummer
US07723527B2

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