Hydrochloric Acid → 6-(Hydroxymethyl)pyridine-3-carboxylic acid

HRID 2242219Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2242219
C[O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[N:6][CH:5]=1.Cl>[OH-].[Na+].CO>[OH:11][CH2:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:12])=[O:2])=[CH:5][N:6]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 7894146-Hydroxymethyl-nicotinic acid methyl ester

Produkt 1

HCID 147221306-(Hydroxymethyl)pyridine-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A solution of 6-hydroxymethyl-nicotinic acid methyl ester (0.400 g, 2.38 mmol) in 1.0 N NaOH (25.0 mL) and methanol (10.0 mL) was heated at 80° C. for 1 hour. The reaction mixture was cooled to room temperature and the pH was adjusted to 7.0 with 1.0 N HCl. The reaction mixture was concentrated in vacuo and the resulting salt was slurried in DMF and filtered to provide the title compound.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-59423fface8b427fb41c791457caea82
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07671043B2

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