Hydrochloric Acid → HCID 178440783, Verbindung

HRID 2242258Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2242258
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][C:14]([C:16]3[CH:32]=[CH:31][C:19]([CH2:20][NH:21][C@@H:22]4[CH2:25][C@H:24]([C:26]([O:28]CC)=[O:27])[CH2:23]4)=[CH:18][CH:17]=3)=[N:13][N:12]=2)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Na+].[ClH:35]>CO>[ClH:35].[CH2:1]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[O:15][C:14]([C:16]3[CH:32]=[CH:31][C:19]([CH2:20][NH:21][C@@H:22]4[CH2:25][C@H:24]([C:26]([OH:28])=[O:27])[CH2:23]4)=[CH:18][CH:17]=3)=[N:13][N:12]=2)=[CH:9][CH:10]=1)[CH:2]([CH3:4])[CH3:3]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178472517HCID 178472517, Verbindung

Produkt 1

HCID 178440783HCID 178440783, VerbindungAusbeute 61 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of ethyl cis-3-({4-[5-(4-isobutylphenyl)-1,3,4-oxadiazol-2-yl]benzyl}amino)cyclobutane carboxylate (0.300 g, 0.692 mmol), 1N NaOH (6.0 mL), and methanol (5 mL) was heated in a microwave oven at 100° C. for 3 minutes. The reaction mixture was cooled to room temperature and pH was adjusted to 7 with 1N HCl, causing a white solid to precipitate. The reaction mixture was filtered and the solid was washed with water, then treated with 1N HC in ether to give the title compound (0.170 g, 61% yield).

Aufarbeitung

  1. customto precipitate
  2. filtrationThe reaction mixture was filtered
  3. washthe solid was washed with water
  4. additiontreated with 1N HC in ether

Quellen und Nachweise

ORD-Eintrag
ord-54b445a372f3416ea4b1d310f9d5982e
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07671043B2

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