Hydrochloric Acid → Methyl 5-(tert-butyl)-2-methoxybenzoate

HRID 2242349Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2242349
Cl.[C:2]([C:6]1[CH:7]=[CH:8][C:9]([O:15][CH3:16])=[C:10]([CH:14]=1)[C:11]([OH:13])=[O:12])([CH3:5])([CH3:4])[CH3:3].[CH3:17]O>>[CH3:17][O:12][C:11](=[O:13])[C:10]1[CH:14]=[C:6]([C:2]([CH3:5])([CH3:3])[CH3:4])[CH:7]=[CH:8][C:9]=1[O:15][CH3:16]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 70103155-Tert-Butyl-2-Methoxybenzoic Acid

Produkt 1

HCID 15724682Methyl 5-(tert-butyl)-2-methoxybenzoateAusbeute 95 %

Versuchsvorschrift

Hydrogen chloride gas was bubbled for 5 min into a stirred solution of 5-tert-butyl-2-methoxybenzoic acid (5.00 g, 24.0 mmol) in methanol (100 ml) at 0° C., after which time the solution was heated under reflux for 17.5 h. The reaction was cooled, evaporated to dryness under reduced pressure and purified by chromatography on silica using diethyl ether as eluent to afford 5-tert-butyl-2-methoxybenzoic acid methyl ester as a pale cream solid (5.06 g, 95%).

Aufarbeitung

  1. temperatureafter which time the solution was heated
  2. temperatureunder reflux for 17.5 h
  3. temperatureThe reaction was cooled
  4. customevaporated to dryness under reduced pressure
  5. custompurified by chromatography on silica

Quellen und Nachweise

ORD-Eintrag
ord-71d8ceecbad14df5be86f1c5ba47b85f
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07671080B2

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