Ethanol → Ethyl 3-amino-2-methylpropanoate hydrochloride

HRID 2242386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2242386
[NH2:1][CH2:2][CH:3]([CH3:7])[C:4]([OH:6])=[O:5].S(Cl)([Cl:10])=O.[CH2:12](O)[CH3:13]>C(Cl)Cl>[ClH:10].[CH2:12]([O:5][C:4](=[O:6])[CH:3]([CH3:7])[CH2:2][NH2:1])[CH3:13]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 64956Beta-Aminoisobutyric Acid

Produkt 1

HCID 19611788Ethyl 3-amino-2-methylpropanoate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

3-Aminoisobutyric acid (1.00 g, 9.7 mmol) was stirred in DCM under nitrogen and thionyl chloride (1.4 ml, 19.4 mmol) was added at room temperature. The reaction was heated to 50° C. for 2 h. The solvent and any excess thionyl chloride were removed under reduced pressure and the oil obtained was dissolved in ethanol (20 ml) stirring at room temperature for 18 h. The solvent was removed under reduced pressure to give 3-aminoisobutyric acid ethyl ester hydrochloride as a viscous, cloudy oil (1.47 g, 90%).

Aufarbeitung

  1. customThe solvent and any excess thionyl chloride were removed under reduced pressure
  2. customthe oil obtained
  3. customThe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6b0fbca56b8d462aa450a7993f682fa6
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07671080B2

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