Dichloromethane → Methyl 2-chloro-4,4-dimethoxy-3-oxopentanoate

HRID 2243049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2243049
[CH3:1][O:2][C:3]([O:12][CH3:13])([CH3:11])[C:4](=[O:10])[CH2:5][C:6]([O:8][CH3:9])=[O:7].C(Cl)[Cl:15]>>[Cl:15][CH:5]([C:4](=[O:10])[C:3]([O:2][CH3:1])([O:12][CH3:13])[CH3:11])[C:6]([O:8][CH3:9])=[O:7]

Komponenten

3

Edukt 2

HCID 6344DichloromethaneHCID 5076552Methyl 4,4-dimethoxy-3-oxopentanoate

Produkt 1

HCID 59208484Methyl 2-chloro-4,4-dimethoxy-3-oxopentanoate

Versuchsvorschrift

SO2Cl2 (2.2 ml, 27 mmol) was added slowly to a solution of 5.0 g (26 mmol) of methyl 4,4-dimethoxy-3-oxopentanoate in 30 ml DCM cooled in an ice water bath. The solution was warmed to room temperature and stirred for 1 h. Solvent was removed and the residue was taken up in EtOAc, which was washed with water and brine. Drying (MgSO4) and removal of solvent gave 6.1 g of an oil. NMR (CDCl3): 1.5 (s, 3H), 3.25 (2s, 6H), 4.8 (s, 3H), 5.3 (s, 1H).

Aufarbeitung

  1. temperaturecooled in an ice water bath
  2. customSolvent was removed
  3. washwhich was washed with water and brine
  4. customDrying
  5. custom(MgSO4) and removal of solvent

Quellen und Nachweise

ORD-Eintrag
ord-64f77c03ad824f44b6c6df81a90cce07
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07674801B2

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