Ethyl isocyanate → 1-(4-Bromopyridin-2-yl)-3-ethylurea

HRID 2243060Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2243060
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[N:9]([CH2:12][CH3:13])=[C:10]=[O:11]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][C:10]([NH:9][CH2:12][CH3:13])=[O:11])[CH:3]=1

Komponenten

4

Edukt 2

HCID 8022Ethyl isocyanateHCID 6932822-Amino-4-bromopyridine

Produkt 1

HCID 592083771-(4-Bromopyridin-2-yl)-3-ethylureaAusbeute 76,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

To a mixture of 4-bromopyridin-2-amine (2 g, 11.56 mmol) in chloroform (10 mL), isocyanatoethane (0.913 mL, 11.56 mmol) was added, and the resulting reaction mixture was heated at 110° C. for 2 h. The reaction mixture was concentrated under reduced pressure and triturated with acetonitrile, then collected by filtered to give the title compound as a white solid (2.15 g).

Aufarbeitung

  1. additionwas added
  2. customthe resulting reaction mixture
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customtriturated with acetonitrile
  5. customcollected
  6. filtrationby filtered

Quellen und Nachweise

ORD-Eintrag
ord-45a5880b52564e1bb2cf746037031595
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07674801B2

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