Iodine → 4-Iodo-2-(trifluoroacetyl)pyrrole

HRID 2243260Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2243260
[F:1][C:2]([F:11])([F:10])[C:3]([C:5]1[NH:6][CH:7]=[CH:8][CH:9]=1)=[O:4].[N+]([O-])([O-])=O.[NH4+].[Ce].[Ce].[I:19]I>C(#N)C>[I:19][C:8]1[CH:9]=[C:5]([C:3](=[O:4])[C:2]([F:1])([F:10])[F:11])[NH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 807IodineHCID 137637Ethanone, 2,2,2-trifluoro-1-(1H-pyrrol-2-yl)-HCID 86617141Dicerium ammonium nitrate

Produkt 1

HCID 592104064-Iodo-2-(trifluoroacetyl)pyrroleAusbeute 112,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

An acetonitrile solution (20 ml) of 2-(trifluoroacetyl)-1H-pyrrole (0.5 g), dicerium ammonium nitrate (0.84 g) and iodine (0.47 g) was refluxed for 2 hours. After cooling, the reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure to obtain 4-iodo-2-(trifluoroacetyl)-1H-pyrrole (0.6 g).

Aufarbeitung

  1. temperatureAfter cooling
  2. washthe reaction solution was washed with saturated aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride
  3. dry with materialAfter drying the organic layer with magnesium sulfate
  4. distillationthe solvent was distilled off under the reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-5a43c9b40c4a49bdb194188d71139fae
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07674807B2

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