Benzyl [2-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate → [2-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetic acid

HRID 2243529Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2243529
[CH:1]([C:4]1[CH:21]=[C:20]([B:22]2[O:26][C:25]([CH3:28])([CH3:27])[C:24]([CH3:30])([CH3:29])[O:23]2)[CH:19]=[CH:18][C:5]=1[O:6][CH2:7][C:8]([O:10]CC1C=CC=CC=1)=[O:9])([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[CH:1]([C:4]1[CH:21]=[C:20]([B:22]2[O:26][C:25]([CH3:28])([CH3:27])[C:24]([CH3:30])([CH3:29])[O:23]2)[CH:19]=[CH:18][C:5]=1[O:6][CH2:7][C:8]([OH:10])=[O:9])([CH3:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 86605504Benzyl [2-isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate

Produkt 1

HCID 23134282[2-Isopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetic acidAusbeute 83,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of benzyl [2-isopropyl-4-(4,4,5,5-tetramethyl -1,3,2-dioxaborolan-2-yl)phenoxy]acetate (0.24 g) and 10% palladium-carbon (0.05 g) in ethanol (10 mL) was stirred at room temperature for 2 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the solvent was evaporated under reduced pressure to afford the title compound (0.156 g).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1c501995b4324ab9b6f54abffc4cf86a
Quelldatensatz
uspto-grants-2010_03
Patentnummer
US07674938B2

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