Carbon Tetrachloride → 1-methyl-3-fluoro-5-phenyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazapin-2-one

HRID 224373

Reaktionsgleichung

Reaktionsgleichung von HRID 224373
[N+:1]([O-])([O:3]C(=O)C)=[O:2].[CH3:8][N:9]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[C:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:12][CH:11]([F:26])[C:10]1=[O:27].C(Cl)(Cl)(Cl)Cl>C(#N)C>[CH3:8][N:9]1[C:15]2[CH:16]=[CH:17][C:18]([N+:1]([O-:3])=[O:2])=[CH:19][C:14]=2[C:13]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[N:12][CH:11]([F:26])[C:10]1=[O:27]

Komponenten

5

Edukt 3

HCID 5943Carbon TetrachlorideHCID 11557Acetyl nitrateHCID 131260013-Fluoro-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Produkt 1

HCID 128110131-methyl-3-fluoro-5-phenyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazapin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

1.2 g. of acetyl nitrate are added dropwise, at 10° to a stirred solution of 2.67 g. of 1-methyl-3-fluoro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one in 70 ml. of CCl4 and 20 ml. of acetonitrile. The mixture is stirred for 1 hour more at 10° and for 3 hours at 20° and is poured into ice cold sodium carbonate solution and worked up in the customary manner to give 1-methyl-3-fluoro-5-phenyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazapin-2-one.

Aufarbeitung

  1. additionis poured into ice cold sodium carbonate solution

Quellen und Nachweise

ORD-Eintrag
ord-bce5adeb8d2842048ace99c84534f42d
Quelldatensatz
uspto-grants-1980_11
Patentnummer
US04232016

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